GENE-SIGNATURE FOR DIAGNOSIS OF EARLY HEPATOCELLULAR CARCINOMA
The incidence of hepatocellular carcinoma (HCC) is 750,000 new cases globally, it is the second leading cause of cancer-related death and represents a major health problem. When identified at early stages, curative treatments such as resection, transplantation and percutaneous ablation are feasible. …
SLICE-SELECTIVE ADIABATIC MAGNETIZATION PREPARATION (SAMPA) FOR T2-WEIGHTED AND DIFFUSION-WEIGHTED IMAGING
Magnetic resonance (MR) imaging at high-fields (3-4.7T) and ultra-high fields (7T and above) leads to higher signal levels with improved image quality, but physical limitations still prevent these systems from being highly efficient. The gold standard for an important MRI method such …
SEMI-ADIABATIC SPECTRAL-SPATIAL SPECTROSCOPIC IMAGING (SASSI)
Proton magnetic resonance spectroscopic imaging (MRSI) can be used as a non-invasive technique for a variety of procedures such as differentiating radiation damage from brain tumors post-therapy, categorizing brain tumors, or investigating neurological and psychiatric diseases like Alzheimer’s and Parkinson’s Disease. However, …
IDENTIFYING THE SUBTYPES OF LEUKEMIA BY CHARACTERIZING THE MUTATIONS OF THE PTPN11 GENE
Intracellular signaling pathways mediate cellular responses to a variety of extracellular signals and dysregulation of such pathways, especially those involved in cell growth and differentiation, is the main cause of cancer. The RAS family of proteins plays key roles in signal transduction, …
A SET OF 3 URINARY BIOMARKERS AS A PROGNOSTIC/DIAGNOSTIC FOR KIDNEY DISEASE
This technology relates to the use of 3 biomarkers present in urine that can be used to predict kidney disease progression. Briefly, Dr. Böttinger and colleagues have discovered a set of 3 biomarkers that can be used over time to determine the …
RoSE Scale (Recognition of Smile Excursion)
At the Mount Sinai Medical Center, Drs. Elliott Rose, Peter Taub, Eric Jablonka and Ilya Shnaydman have developed the digitally based RoSE Facial Grading System software program for portable tablets (iPads) and computers to objectively measure smile (facial expression) symmetry in the …
A VERSATILE IN VIVO RNA-INTERFERENCE DELIVERY PLATFORM
The ability to deliver miRNAs or small interfering RNAs (siRNAs) in vivo has been a major hurdle in harnessing the power of RNA interference. This platform technology employs RNA virus-like vectors to deliver functional small RNAs to any tissue of interest. Depending …
MODIFIED VERO CELLS WITH SUPPRESSED INNATE IMMUNE RESPONSES AND ENHANCED VIRUS PRODUCTION
Dr. Chris Basler and colleagues have developed a stable cell line with enhanced virus replication and production efficiency. The Vero 76 cell line (ATCC No. CCL-1587) has been widely used for cell-based research and product development (1, 2, 4). Several characteristics of …
PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA AND NOTCH3 RECEPTOR MODULATORS FOR THE TREATMENT OF INFANTILE MYOFIBROMATOSIS
Infantile myofibromatosis (IMF) is one of the most common proliferative fibrous tumors of infancy and childhood. IMF is a disorder of mesenchymal proliferation characterized by the development of non-metastasizing tumors in the skin, muscle, bone and viscera. Occurrence within families across multiple …