Startup Companies

Learn more about the healthcare and biotechnology startup companies powered by technology developed at Mount Sinai.


Precision diagnostics company focused on the detection and management of life-threatening food allergies, aiming to help providers safely assess and monitor patients, and to grow a database of phenotypic patient data on epitope mapping, clinical history, and patient-reported outcomes.

Amathus Therapeutics
Biopharmaceutical company advancing the development of small molecule therapeutics for the treatment of neurodegenerative and renal disorders, including Parkinson’s disease and kidney disease.

CastleVax Inc.
Leading vaccine platform company based on technology developed at the Icahn School Medicine at Mount Sinai. The CastleVax platform utilizes Newcastle Disease Virus (NDV) to induce the human immune system to produce neutralizing antibodies targeted at a range of emerging and pandemic viruses, such as SARS-CoV-2 and other infectious viruses that attack the human respiratory system and other vital organs. The technology was developed in response to the growing need for vaccine independence and pandemic response preparedness.

Click Therapeutics
Digital therapeutics company that develops, validates, and commercializes software as prescription medical treatments for a variety of conditions. The Emotional Faces Memory Task (EFMT) technology used in the company’s digital therapeutic to treat major depressive disorder, known as CT-152, was originally developed by Mount Sinai researchers.

Acute-care services company that is utilizing Mount Sinai’s Hospitalization at Home and Palliative Care at Home programs to expand outpatient, ambulatory and home-based care capabilities.

A genetic testing company delivering personalized and actionable health insights to inform diagnosis, direct treatment, and improve drug discovery. GeneDx aims to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care.

Kantaro Biosciences
Based on underlying technology developed at Mount Sinai, Kantaro is a joint venture between Mount Sinai and Renalytix to develop and scale production of rigorous, results-driven and reproducible diagnostic and serology tests for critical health challenges, with an initial focus on COVID-19. Kantaro was granted emergency use authorization by the FDA in April 2020. Kantaro was named to Fast Company’s World’s Most Innovative Companies 2021 list, ranking first in the Joint Venture category, and was a finalist for the World’s Changing Ideas in the Pandemic Response category.

Linus Biotechnology 
A patient-centric precision exposome medicine company, Linus Biotechnology (LinusBio) is a startup company focused on the development of diagnostics and prognostics that are based on past environmental exposures of individuals. The company’s initial diagnostic, StrandDx-ASD, was developed at Mount Sinai and received Breakthrough Device designation from the U.S. FDA for Autism Spectrum Disorder in 2021.

Monogram Orthopedics
Monogram Orthopedics is developing 3D printed custom implants for patients and a state-of-the-art robot that prepares the bones into which the implants are inserted for less invasive and more precise joint reconstruction surgery. Monogram went public on NASDAQ in 2023.

An augmented intelligence healthcare services provider delivering patient-specific insights that aid in disease state characterization and enable better treatment decisions and outcomes.


Diagnostics company (NASDAQ: RNLX) powered by KidneyIntelX, a prognostic test developed in conjunction with Mount Sinai that identifies individuals who will rapidly progress towards kidney failure. KidneyIntelX, which received FDA De Novo Marketing Authorization in 2023, allows clinicians to assess the risk of progressive kidney function decline in patients in type 2 diabetes and early-stage chronic kidney disease to optimize their care and promote better outcomes.

Enterprise-grade digital health platform enabling evidence-based automated care plans to be prescribed via electronic health records and care management systems. Rx.Health is now a part of Commure Engage, a platform that aims to advance clinical care coordination.

Trellus Health
Trellus Health is a connected health solution for complex, chronic conditions that addresses physical and behavioral health. Through its resilience-driven methodology, Trellus utilizes clinical expertise and multidisciplinary methods to connect patients and caregivers with experts, coaches, tools, and resources for a total care approach. The first-of-its-kind startup secured $5 million in seed funding in 2020 and was listed on the London Stock Exchange’s Alternative Investment Market (AIM) for small to medium growth companies in May 2021.

Verici Dx
Verici Dx is developing advanced clinical diagnostics to understand how a patient will and is responding to organ transplant, with an initial focus on kidney transplants. Verici Dx’s commercial clinical offerings, Clarava™, Tuteva™, and Protega™, were developed at Mount Sinai.