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Therapeutic

RGFP996; A SPECIFIC HDAC3 INHIBITOR FOR TREATING ACUTE SPINAL CORD INJURY

September 13, 2016

There are approximately 12,500 new cases of acute SCI (spinal cord injury) each year  in the United States, with that number expected to rapidly increase with the rise in the aging population. The only current treatment for SCI, albeit controversial, is the use …

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Therapeutic

SERCA2a TREATMENT FOR PULMONARY HYPERTENSION

October 13, 2015

Pulmonary arterial hypertension (PAH) commonly results from heart failure in the left side of the heart or from a pulmonary embolism, when a blood clot in the leg travels to the lungs and cause blockages. When the lung is damaged from these …

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Therapeutic

SOLUBLE INHIBITORS OF HIV-1 FROM CD8+ CELLS

September 21, 2015

CD8+ T-cells have been shown to secrete soluble factors that can effectively inhibit HIV replication. Researchers at Mount Sinai, led by Dr. Mary Klotman have identified and characterized key products from CD8+ cells that not only enhance the understanding of the HIV …

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Therapeutic

HYBRID FUSION PROTEIN TRANSCRIPTION REGULATOR – A NOVEL ANTIVIRAL THERAPY

September 21, 2015

Background: Two families of transcriptional regulators, members of the “signal transducers and activators of transcription” (STAT) and “interferon regulatory factor” (IRF) families, work in conjunction to establish a cascade of gene regulation and signal transduction events that lead to transcriptional activation of …

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Therapeutic

EXPANDED CORD BLOOD STEM CELLS FOR USE AS TRANSPLANTATION GRAFTS

July 31, 2014

Scientists in Drs. Hoffman and Chaurasia’s laboratories have developed a novel approach to substantially expand the numbers of functional Cord blood (CB) hematopoietic stem cells (HSCs) while maintaining true stem cell engraftment capability. Cord blood (CB) cells that express CD34 have extensive …

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Therapeutic

THE USE OF CEACAM5 PEPTIDES AS AN IMMUNOTHERAPY FOR CROHN’S DISEASE

May 30, 2014

Crohn’s Disease (CD) is a chronic relapsing/remitting inflammatory disease of the gastrointestinal tract affecting about 800,000 patients in the US and Europe alone with rising incidence rates. In addition to reduced quality of life for CD patients, the chronic inflammation associated with …

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Therapeutic

CONSTRUCTION OF REASSORTMENT-DEFICIENT INFLUENZA VIRUS

May 29, 2014

An effective way to protect against influenza infection is through vaccination with attenuated influenza virus. However, due to reassortment, co-infection of an individual with a live attenuated vaccine strain and a wild-type strain of influenza may enable formulation of replication-competent virus carrying …

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Therapeutic

LOW DOSE PROTEASOME INHIBITOR SENSITIZES PI3K RESISTANT CANCERS TO TREATMENT WITH PI3K PATHWAY INHIBITORS

May 29, 2014

Resistance to PI3 kinase pathway inhibitors can occur through changes in cancer signaling pathways. “Priming” with subtherapeutic doses bortezomib leads to activation of and reliance on the PI3 kinase pathway, making cancers susceptible to PI3 kinase pathway inhibitors. Dr. Ross Cagan and members …

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Therapeutic

INSULIN-LIKE GROWTH FACTOR-1 FOR PHELIN-McDERMID SYNDROME, A RARE AUTISM-RELATED SYNDROME

May 29, 2014

Phelin-McDermid Syndrome (PMS) is a rare genetic syndrome, with a wide range of severity of symptoms, including intellectual disabilities, sleep disorders, and seizures, as well as motor and vocalization symptoms. PMS is caused by disruption of the SHANK3/ProSAP2 gene on the terminal …

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Therapeutic

PARAMYXOVIRUSES AS VACCINE VECTORS FOR LARGE FOREIGN ANTIGENS

May 14, 2014

This technology describes a method that increases the ability of paramyxoviruses to encode a large foreign antigen for development of vaccines. Recombinant paramyxoviruses encoding small foreign antigens have been successful at eliciting specific cellular and immune responses and some have also been …

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