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Therapeutic

NOVEL MICRO-RNA THERAPY FOR TREATMENT OF DRAVET SYNDROME, A PEDIATRIC ORPHAN DISEASE

April 24, 2014

Dravet syndrome (DS), also known as severe myoclonic epilepsy of infancy (SMEI), is a genetic and rare form of treatment-refractory epilepsy that begins in infancy. DS incidence is estimated at 1/30,000 with about 20,000-40,000 patients worldwide. The long-term prognosis for DS patients …

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Therapeutic

USE OF FLUOXETINE TO TREAT AUTISM SPECTRUM DISORDER

April 24, 2014

Autism spectrum disorder (ASD) is a collection of development disorders characterized by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. In addition to social deficits, ASD can also result in intellectual delays, irritability, problems with motor coordination, and additional …

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Therapeutic

USE OF MEMANTINE TO TREAT AUTISM AND ASSOCIATED DISORDERS

April 24, 2014

Autism spectrum disorder (ASD) is a collection of development disorders of unknown etiology characterized by difficulties in social interaction, verbal and nonverbal communication and repetitive behaviors. In addition to social deficits, ASD can also result in intellectual delays, irritability, problems with motor coordination, …

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Therapeutic

NOVEL THERAPY TO REDUCE SUICIDAL IDEATION ASSOCIATED WITH SSRI USE

April 23, 2014

Major Depressive Disorder (depression) is a mental disorder with symptoms including low mood, low self-esteem and loss of pleasure. Approximately 14.8 million patients in the US are affected by depression. Selective Serotonin Reuptake Inhibitors (SSRIs) are commonly used in patients to treat depression, as …

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Therapeutic

A NOVEL METHOD TO TREAT ALZHEIMER’S DISEASE AND TUMOR METASTASIS

March 25, 2014

Alzheimer’s disease (AD) is the most common age-associated dementia. It is a progressive neurodegenerative disorder that correlates with the accumulation of abnormally aggregated amyloid beta (Ab) in the brain.  Current therapeutic options do not treat the underlying disease and have several side …

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Therapeutic

NOVEL METHOD TO SPECIFICALLY INHIBIT CATHEPSIN K COLLAGENOLYTIC ACTIVITY

March 19, 2014

Bone homeostasis is a complex process and requires a balance between bone formation and resorption.  Cathepsin K is a collagenase which is highly expressed in bone resorbing cells and its deficiency leads to pycnodysostosis, a rare disease characterized by a decrease in …

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