METHOD TO DETERMINE CAUSAL RELATIONSHIPS IN COMPLEX NETWORKS
Elucidating causal relationships between the components within complex networks has impact in commercial and research applications. For example, the ability to understand causal relationships of the components that determine stock prices can predict how the stock market will behave. In biomedical research, …
NOVEL HIGH THROUGHPUT SCREEN TO IDENTIFY REGULATORS OF UBIQUITIN LIGASE ACTIVITY
Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 and E3), tightly regulates cellular protein turnover. It plays a key role in cellular proliferation and inflammation and is associated with a multitude of diseases, including cancer, metabolic …
POTENT NEUTRALIZING MONOCLONAL ANTIBODIES TO HCMV
This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly more potent than the currently marketed alternative Cytogam™. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV patients, organ …
HIGH-THROUGHPUT ASSAY FOR INHIBITORS OF HIV’S CELL-TO-CELL TRANSMISSION
This technology allows the identification of a new class of antiviral drugs that inhibit the transmission of the Human Immunodeficiency Virus (HIV) through the virological synapse. Although there are several effective treatments for HIV, it continues to remain an incurable condition that …
DNA LOCK™: A NOVEL AND SECURE DNA-BASED AUTHENTICATION METHOD
Seized, counterfeit goods in the United States in 2012 were estimated to be worth over $1.30 billion. Current marking techniques can be recovered, copied and illegally used to mark counterfeited goods. To control this increasing problem, reliable counterfeit-resistant techniques are required. Scientists …