SOLUBLE INHIBITORS OF HIV-1 FROM CD8+ CELLS
CD8+ T-cells have been shown to secrete soluble factors that can effectively inhibit HIV replication. Researchers at Mount Sinai, led by Dr. Mary Klotman have identified and characterized key products from CD8+ cells that not only enhance the understanding of the HIV …
CONSTRUCTION OF REASSORTMENT-DEFICIENT INFLUENZA VIRUS
An effective way to protect against influenza infection is through vaccination with attenuated influenza virus. However, due to reassortment, co-infection of an individual with a live attenuated vaccine strain and a wild-type strain of influenza may enable formulation of replication-competent virus carrying …
PARAMYXOVIRUSES AS VACCINE VECTORS FOR LARGE FOREIGN ANTIGENS
This technology describes a method that increases the ability of paramyxoviruses to encode a large foreign antigen for development of vaccines. Recombinant paramyxoviruses encoding small foreign antigens have been successful at eliciting specific cellular and immune responses and some have also been …
POTENT NEUTRALIZING MONOCLONAL ANTIBODIES TO HCMV
This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly more potent than the currently marketed alternative Cytogam™. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV patients, organ …
HIGH-THROUGHPUT ASSAY FOR INHIBITORS OF HIV’S CELL-TO-CELL TRANSMISSION
This technology allows the identification of a new class of antiviral drugs that inhibit the transmission of the Human Immunodeficiency Virus (HIV) through the virological synapse. Although there are several effective treatments for HIV, it continues to remain an incurable condition that …
NOVEL LIVE ATTENUATED INFLUENZA VIRUS VACCINES
This technology takes advantage of the species-specific expression of miRNAs to generate live attenuated influenza virus vaccines (LAIVs) alleviating all manufacturing constraints and the necessity of relying on cold-adapted mutants. This technology is enabled by the silent insertion of perfect miRNA target …
MODIFIED VERO CELLS WITH SUPPRESSED INNATE IMMUNE RESPONSES AND ENHANCED VIRUS PRODUCTION
Dr. Chris Basler and colleagues have developed a stable cell line with enhanced virus replication and production efficiency. The Vero 76 cell line (ATCC No. CCL-1587) has been widely used for cell-based research and product development (1, 2, 4). Several characteristics of …