SOLUBLE INHIBITORS OF HIV-1 FROM CD8+ CELLS
CD8+ T-cells have been shown to secrete soluble factors that can effectively inhibit HIV replication. Researchers at Mount Sinai, led by Dr. Mary Klotman have identified and characterized key products from CD8+ cells that not only enhance the understanding of the HIV …
HYBRID FUSION PROTEIN TRANSCRIPTION REGULATOR – A NOVEL ANTIVIRAL THERAPY
Background: Two families of transcriptional regulators, members of the “signal transducers and activators of transcription” (STAT) and “interferon regulatory factor” (IRF) families, work in conjunction to establish a cascade of gene regulation and signal transduction events that lead to transcriptional activation of …
SLICE-SELECTIVE ADIABATIC MAGNETIZATION PREPARATION (SAMPA) FOR T2-WEIGHTED AND DIFFUSION-WEIGHTED IMAGING
Magnetic resonance (MR) imaging at high-fields (3-4.7T) and ultra-high fields (7T and above) leads to higher signal levels with improved image quality, but physical limitations still prevent these systems from being highly efficient. The gold standard for an important MRI method such …
SEMI-ADIABATIC SPECTRAL-SPATIAL SPECTROSCOPIC IMAGING (SASSI)
Proton magnetic resonance spectroscopic imaging (MRSI) can be used as a non-invasive technique for a variety of procedures such as differentiating radiation damage from brain tumors post-therapy, categorizing brain tumors, or investigating neurological and psychiatric diseases like Alzheimer’s and Parkinson’s Disease. However, …
MATCHED-PHASE SEMI-ADIABATIC MULTI-SLICE SPIN-ECHO PINS PULSE PAIR
There are still several challenges in acquiring high-quality MR images when using high magnetic field systems, such as the 7 Tesla. Three key issues prevent these systems from functioning at their highest potential: (1) nonuniformities in signal and contrast due to increased …
NeoStem, Inc. and AllCells, LLC to collaborate with Mount Sinai as part of $8.8 million Grant to Further Stem Cell Research
April 16, 2015 – Icahn School of Medicine at Mount Sinai (ISSMM) will be able to further develop new blood treatments for chemotherapy-resistant blood cancer and other genetic blood disorders thanks to an $8.8 million grant from the New York State Stem …
Philips and Mount Sinai Health System collaborate to advance clinical research through new digital pathology database and analytics
March 24, 2015 – Royal Philips (NYSE: PHG, AEX: PHIA) today announced a joint development agreement with the Mount Sinai Health System, an integrated health system in New York, to create a state-of-the-art digital image repository of patient tissue samples and innovative data analytics to pursue the …
Icahn School of Medicine at Mount Sinai and LifeMap Solutions Launch Asthma Study for iPhone
March 9, 2015 – The Icahn School of Medicine at Mount Sinai and LifeMap Solutions, a subsidiary of BioTime (BTX), today announced the launch of a large-scale medical research study that uses the new ResearchKit framework developed by Apple to make it …
METHOD TO DETERMINE CAUSAL RELATIONSHIPS IN COMPLEX NETWORKS
Elucidating causal relationships between the components within complex networks has impact in commercial and research applications. For example, the ability to understand causal relationships of the components that determine stock prices can predict how the stock market will behave. In biomedical research, …
IDENTIFYING THE SUBTYPES OF LEUKEMIA BY CHARACTERIZING THE MUTATIONS OF THE PTPN11 GENE
Intracellular signaling pathways mediate cellular responses to a variety of extracellular signals and dysregulation of such pathways, especially those involved in cell growth and differentiation, is the main cause of cancer. The RAS family of proteins plays key roles in signal transduction, …