EXPANDED CORD BLOOD STEM CELLS FOR USE AS TRANSPLANTATION GRAFTS
Scientists in Drs. Hoffman and Chaurasia’s laboratories have developed a novel approach to substantially expand the numbers of functional Cord blood (CB) hematopoietic stem cells (HSCs) while maintaining true stem cell engraftment capability. Cord blood (CB) cells that express CD34 have extensive …
Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C
July 22, 2014 – Neurotrope Bioscience, Inc., a subsidiary of Neurotrope, Inc. (otcqb:NTRP) has signed a world-wide, exclusive license agreement with the Icahn School of Medicine at Mount Sinai (Mount Sinai) to utilize its proprietary information and data package for the use …
A SET OF 3 URINARY BIOMARKERS AS A PROGNOSTIC/DIAGNOSTIC FOR KIDNEY DISEASE
This technology relates to the use of 3 biomarkers present in urine that can be used to predict kidney disease progression. Briefly, Dr. Böttinger and colleagues have discovered a set of 3 biomarkers that can be used over time to determine the …
THE USE OF CEACAM5 PEPTIDES AS AN IMMUNOTHERAPY FOR CROHN’S DISEASE
Crohn’s Disease (CD) is a chronic relapsing/remitting inflammatory disease of the gastrointestinal tract affecting about 800,000 patients in the US and Europe alone with rising incidence rates. In addition to reduced quality of life for CD patients, the chronic inflammation associated with …
RoSE Scale (Recognition of Smile Excursion)
At the Mount Sinai Medical Center, Drs. Elliott Rose, Peter Taub, Eric Jablonka and Ilya Shnaydman have developed the digitally based RoSE Facial Grading System software program for portable tablets (iPads) and computers to objectively measure smile (facial expression) symmetry in the …
IMPLANTABLE SPINAL RADIATION SHIELD DELIVERABLE BY OPEN OR MINIMALLY INVASIVE SURGERY
The spinal radiation shield is designed to relieve spinal cord compression caused by spinal metastatic disease, as well as allow for higher dose radiotherapy treatments such as brachytherapy and external beam radiation. Dr. Arthur L. Jenkins, III, Neurosurgeon and Head of the Spinal …
CONSTRUCTION OF REASSORTMENT-DEFICIENT INFLUENZA VIRUS
An effective way to protect against influenza infection is through vaccination with attenuated influenza virus. However, due to reassortment, co-infection of an individual with a live attenuated vaccine strain and a wild-type strain of influenza may enable formulation of replication-competent virus carrying …
MAGNETIC NEEDLE RETRIEVER
The magnetic needle retrieval device is designed to fit through standard laparoscopic, endoscopic or robotic surgery ports to retrieve lost metal surgical needles, clips, foreign bodies, etc. Dr. Michael Palese, Director of Minimally Invasive Urology, and Dr. Daniel Gainsburg, Associate Professor of …
NOVEL HIGH THROUGHPUT SCREEN TO IDENTIFY REGULATORS OF UBIQUITIN LIGASE ACTIVITY
Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 and E3), tightly regulates cellular protein turnover. It plays a key role in cellular proliferation and inflammation and is associated with a multitude of diseases, including cancer, metabolic …
LOW DOSE PROTEASOME INHIBITOR SENSITIZES PI3K RESISTANT CANCERS TO TREATMENT WITH PI3K PATHWAY INHIBITORS
Resistance to PI3 kinase pathway inhibitors can occur through changes in cancer signaling pathways. “Priming” with subtherapeutic doses bortezomib leads to activation of and reliance on the PI3 kinase pathway, making cancers susceptible to PI3 kinase pathway inhibitors. Dr. Ross Cagan and members …