INSULIN-LIKE GROWTH FACTOR-1 FOR PHELIN-McDERMID SYNDROME, A RARE AUTISM-RELATED SYNDROME
Phelin-McDermid Syndrome (PMS) is a rare genetic syndrome, with a wide range of severity of symptoms, including intellectual disabilities, sleep disorders, and seizures, as well as motor and vocalization symptoms. PMS is caused by disruption of the SHANK3/ProSAP2 gene on the terminal …
PARAMYXOVIRUSES AS VACCINE VECTORS FOR LARGE FOREIGN ANTIGENS
This technology describes a method that increases the ability of paramyxoviruses to encode a large foreign antigen for development of vaccines. Recombinant paramyxoviruses encoding small foreign antigens have been successful at eliciting specific cellular and immune responses and some have also been …
INHIBITION OF TNF ALPHA ACTIVATION OF NFKB BY PENTOSAN POLYSULFATE
Researchers have discovered that Pentosan polysulfate acts through inhibiting TNF-alpha-mediated NFKB activation, and that it could have broad anti-inflammatory applications. The most promising applications of the technology include prevention of formation and rupture of atherosclerotic plaque, and reduction of damage to the …
METHODS FOR PROGRAMMING DIFFERENTIATED CELLS INTO HEMATOPOIETIC STEM CELLS
This technology defines a specific combination of transcription factors that can program hemogenesis in fibroblasts. The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation. Transplantation of HSCs is utilized cell therapy …
SUTURE-FREE TROCAR SITE CLOSURE DEVICE
The trocar site closure device is designed to rapidly close trocar (port) sites without the need for sutures. Currently, trocar sites of 10mm or higher in adult cases and all trocar sites in pediatric cases require closure to avoid a possible trocar …
GENIPIN-CROSSLINKED FIBRIN HYDROGEL FOR SOFT TISSUE REPAIR
The genipin-crosslinked fibrin hydrogel (FibGen) is a stiff, biocompatible hydrogel intended to fill tissue defects in load bearing tissue, and this particular formulation has the addition of fibronectin or collagen to enhance cell viability, proliferation and phenotypic characteristics. Dr. James Iatridis and …
POTENT NEUTRALIZING MONOCLONAL ANTIBODIES TO HCMV
This technology relates to a Human Cytomegalovirus (HCMV) neutralizing monoclonal antibody that is significantly more potent than the currently marketed alternative Cytogam™. HCMV infection is typically unnoticed in healthy people, but can be life-threatening for the immunocompromised, such as HIV patients, organ …
HIGH-THROUGHPUT ASSAY FOR INHIBITORS OF HIV’S CELL-TO-CELL TRANSMISSION
This technology allows the identification of a new class of antiviral drugs that inhibit the transmission of the Human Immunodeficiency Virus (HIV) through the virological synapse. Although there are several effective treatments for HIV, it continues to remain an incurable condition that …
A VERSATILE IN VIVO RNA-INTERFERENCE DELIVERY PLATFORM
The ability to deliver miRNAs or small interfering RNAs (siRNAs) in vivo has been a major hurdle in harnessing the power of RNA interference. This platform technology employs RNA virus-like vectors to deliver functional small RNAs to any tissue of interest. Depending …
IN VIVO RNAi SCREEN FOR THE IDENTIFICATION OF HOST FACTORS RESTRICTING VIRAL REPLICATION
This technology allows the identification of host restriction factors that limit viral replication in a relevant animal model. Standard siRNA screens are most often conducted in vitro using transformed cell lines and are therefore inherently non-physiological. However, by enabling siRNA delivery through …