RoSE Scale (Recognition of Smile Excursion)
At the Mount Sinai Medical Center, Drs. Elliott Rose, Peter Taub, Eric Jablonka and Ilya Shnaydman have developed the digitally based RoSE Facial Grading System software program for portable tablets (iPads) and computers to objectively measure smile (facial expression) symmetry in the …
IMPLANTABLE SPINAL RADIATION SHIELD DELIVERABLE BY OPEN OR MINIMALLY INVASIVE SURGERY
The spinal radiation shield is designed to relieve spinal cord compression caused by spinal metastatic disease, as well as allow for higher dose radiotherapy treatments such as brachytherapy and external beam radiation. Dr. Arthur L. Jenkins, III, Neurosurgeon and Head of the Spinal …
CONSTRUCTION OF REASSORTMENT-DEFICIENT INFLUENZA VIRUS
An effective way to protect against influenza infection is through vaccination with attenuated influenza virus. However, due to reassortment, co-infection of an individual with a live attenuated vaccine strain and a wild-type strain of influenza may enable formulation of replication-competent virus carrying …
MAGNETIC NEEDLE RETRIEVER
The magnetic needle retrieval device is designed to fit through standard laparoscopic, endoscopic or robotic surgery ports to retrieve lost metal surgical needles, clips, foreign bodies, etc. Dr. Michael Palese, Director of Minimally Invasive Urology, and Dr. Daniel Gainsburg, Associate Professor of …
NOVEL HIGH THROUGHPUT SCREEN TO IDENTIFY REGULATORS OF UBIQUITIN LIGASE ACTIVITY
Protein ubiquitination, a multi-step process utilizing a cascade of three enzyme classes (E1, E2 and E3), tightly regulates cellular protein turnover. It plays a key role in cellular proliferation and inflammation and is associated with a multitude of diseases, including cancer, metabolic …
LOW DOSE PROTEASOME INHIBITOR SENSITIZES PI3K RESISTANT CANCERS TO TREATMENT WITH PI3K PATHWAY INHIBITORS
Resistance to PI3 kinase pathway inhibitors can occur through changes in cancer signaling pathways. “Priming” with subtherapeutic doses bortezomib leads to activation of and reliance on the PI3 kinase pathway, making cancers susceptible to PI3 kinase pathway inhibitors. Dr. Ross Cagan and members …
INSULIN-LIKE GROWTH FACTOR-1 FOR PHELIN-McDERMID SYNDROME, A RARE AUTISM-RELATED SYNDROME
Phelin-McDermid Syndrome (PMS) is a rare genetic syndrome, with a wide range of severity of symptoms, including intellectual disabilities, sleep disorders, and seizures, as well as motor and vocalization symptoms. PMS is caused by disruption of the SHANK3/ProSAP2 gene on the terminal …
PARAMYXOVIRUSES AS VACCINE VECTORS FOR LARGE FOREIGN ANTIGENS
This technology describes a method that increases the ability of paramyxoviruses to encode a large foreign antigen for development of vaccines. Recombinant paramyxoviruses encoding small foreign antigens have been successful at eliciting specific cellular and immune responses and some have also been …
INHIBITION OF TNF ALPHA ACTIVATION OF NFKB BY PENTOSAN POLYSULFATE
Researchers have discovered that Pentosan polysulfate acts through inhibiting TNF-alpha-mediated NFKB activation, and that it could have broad anti-inflammatory applications. The most promising applications of the technology include prevention of formation and rupture of atherosclerotic plaque, and reduction of damage to the …
METHODS FOR PROGRAMMING DIFFERENTIATED CELLS INTO HEMATOPOIETIC STEM CELLS
This technology defines a specific combination of transcription factors that can program hemogenesis in fibroblasts. The blood system is continuously replenished from a rare population of hematopoietic stem cells (HSCs) that balance self-renewal and differentiation. Transplantation of HSCs is utilized cell therapy …